Michelle Obama And The Baddest Woman In The World (PHOTOS)

3. The Big O, Oprah Winfrey

The world's most successful female media exec she earned $1.35 billion over the last five years--is making some big changes for 2010-11. Her 25th season of Oprah, the program that has launched multiple careers, spawned countless bestsellers and helped millions of women feel that someone, at last, understands them, will air its final show on Sept. 9, 2011.