The two were spotted on several occasions yesterday in Milan just casually hanging out, whipping the fans and paparazzi into a frenzy.
Both Donatella and Gaga are giants in their respective fields, so we guess they have a lot to talk about in that regard - despite the 30-year age difference.
The two posed for pictures together, showed off Gaga's dog Fozzie Bear on the balcony of Donatella's Milanese home, and threw flowers to the adoring crowd.
Throughout the day Gaga had numerous outfit changes, which included a slinky bright-red tight fitted dress, that also included a hair change to a reddish brown hue very reminiscent of Jessica Rabbit.
Her next outfit was a black and gold silk jacket, following by a leather dress held together by pins. Of course, all Gaga's outfit choices were designed by Versace.
You can check out some of the pictures from Gaga and Donatella's shenanigan-filled night out in Milan in the gallery above!